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Scientist, Cellular and Genetic Engineering

Company: InVitro Cell Research, LLC
Location: New York
Posted on: November 11, 2019

Job Description:

ICR is seeking an exceptionally talented scientist with expertise in cellular genetic engineering and human molecular genetics. The ideal candidate will have a record of accomplishment in stem cell genetic engineering, AAV-mediated gene therapy and current gene-editing technologies.
We're looking for someone with the drive and determination to contribute to our current efforts and bring novel, practical and readily translatable ideas to our developmental pipeline. The candidate will explore novel pathways in regenerative and anti-aging translational research using AAV-mediated gene therapy as well as genetically engineered stem cell-based technologies, including cell therapy itself and engineered cell-derived extracellular vesicles (e.g. exosomes). ICR is dedicated to slowing human aging, increasing health span and preventing age-related disease while accelerating the development of practical regenerative medicine technologies. With these goals in mind, we have on-going programs developing next-generation interventions for aging and the major age-related diseases.
Key Goals and Responsibilities:

  • Contribute to the design and production of genetically engineered cell-based interventions for multiple age-related diseases and regenerative medicine projects
  • Identify and evaluate candidate genes for age-reversal and prevention of age-related diseases
  • Design of and efficacy and safety testing of AAV-mediated delivery of select genes to target cells and tissues in vitro and in vivo
  • Testing various modification paradigms to improve targeting and efficiency of AAV-mediated gene delivery
  • Contribute novel and practical ideas to ICR's AAV-mediated gene therapy program, including applications involving AAV-CRISPR/Cas9 technologies and NGS technology platforms
  • Collaborate with internal and external groups to maximize productivity and performance
    Minimum Qualifications:
    • PhD or MD, PhD in a biomedical science field
    • 5 to 10+ years experience with gene therapy and genetic/cellular engineering
    • Expert knowledge of latest-generation CRISPR-based gene editing technologies as well as NGS sequencing platforms such as the Illumina NextSeq 550
    • Experience with and expert knowledge of AAV-mediated gene therapy
      Preferred Qualifications:
      • Experience with adult stem cells and iPSC-derived cells, including mesenchymal and hematopoietic stem cells
      • Expert knowledge in experimental therapeutics and the therapeutic pipeline landscape for AAV, including gene and cellular therapy applications for muscle regeneration, vascular endothelial rejuvenation and other tissue/organ-specific regeneration paradigms
      • General and working knowledge of aging biology, disease of human aging, and regenerative and personalized medicine
        Additional Requirements:
        • Excellent English-language communication skills
        • Ability to work in the United States without sponsorship

Keywords: InVitro Cell Research, LLC, New York , Scientist, Cellular and Genetic Engineering, Engineering , New York, New York

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