Director, Medicinal Chemistry
Location: New York
Posted on: May 16, 2022
Director, Medicinal Chemistry
Job ID: 2021-1615
Type: Regular Full-Time
# of Openings: 1
Category: Research & Development
Deerfield Discovery and Development, LLC (3DC) engages in drug
discovery research in collaboration with premier universities and
biopharmaceutical companies across the United States. 3DC is the
drug discovery arm of Deerfield Management Company, L.P.
("Deerfield"), an investment firm dedicated to advancing
healthcare. The goal of 3DC is to enable portfolio companies of
Deerfield's investment funds to create a pipeline of medically
important and commercially viable projects at a scale sufficient to
produce value for patients and investors. Project teams consist of
scientists from a wide variety of disciplines (chemistry, biology,
DMPK, toxicology, computational science, software and automation
engineering), working together in a highly collaborative
environment to advance these goals.
Title: Director, Medicinal Chemistry
We seek an entrepreneurial Medicinal Chemist with strong technical
and problem-solving skills in Organic and Medicinal Chemistry, to
serve as Director, Medicinal Chemistry for 3DC. The successful
candidate will join an emerging company with a unique approach to
discovering next-generation small molecule therapeutics.
The ideal candidate is well-versed and experienced in medicinal
chemistry and organic synthesis ; has experience managing
outsourcing of medicinal chemistry-related activities; and has
exceptional written and oral communication skills, interpersonal
skills and critical thinking skills. The candidate will have
experience applying (i) structure-based drug design, including
optimization of potency, and selectivity and (ii) in vitro and in
vivo ADMET data, including interpretation of PK/PD studies, to lead
optimization. Experience contributing to and leading multiple
programs from Hit Identification to Clinical Candidate is highly
Working collaboratively with colleagues from Discovery Biology,
Computational Chemistry, Translational Sciences, DMPK, Process
Chemistry and Safety Assessment , provide functional expertise and
leadership across a portfolio of small molecule projects resulting
from our academic collaborations
Provide leadership in the design, synthesis and characterization of
molecules as part of drug discovery efforts.
Develop Structure Activity Relationships (SAR) and conduct
multi-parameter optimization to identify high-quality drug
Provide functional expertise and input in the development of work
plans (from lead identification to drug candidate selection) for
small molecule programs
Coordinate and oversee outsourced synthesis and biological
evaluation of lead compounds
Contribute to development of novel chemical approaches to
Contribute to intellectual property.
Ph.D. in organic chemistry with hands-on Medicinal Chemistry
experience and a track record of accomplishment in the
Deep knowledge and demonstrated problem-solving skills in Synthetic
Organic and Medicinal Chemistry
Significant experience applying structural information and
molecular modeling to the drug design process
Have a deep understanding of organic chemical reactivity and
complex molecule synthesis.
Hands-on experience with modern analytical instrumentation to
elucidate chemical structures.
Excellent understanding of the drug discovery process and a proven
track record of contributing to the identification of lead
compounds and clinical candidates.
Strong oral and written communication skills.
Excellent team player.
Have experience coordinating outsourced Synthetic Organic and
Medicinal Chemistry programs.
3DC provides equal employment opportunities (EEO) to all employees
and applicants for employment without regard to religion, race,
creed, color, sex, sexual orientation, alienage or citizenship
status, national origin, age, marital status, pregnancy,
disability, veteran or military status, predisposing genetic
characteristics or any other characteristic protected by applicable
federal, state or local law.
Keywords: 3DC, New York , Director, Medicinal Chemistry, Executive , New York, New York
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