Senior Associate Scientist, RNA Biology - Viral Vaccine
Company: Pfizer
Location: Pearl River
Posted on: May 16, 2022
Job Description:
Why Patients Need YouPfizer's purpose is to deliver
breakthroughs that change patients' lives. Research and Development
is at the heart of fulfilling Pfizer's purpose as we work to
translate advanced science and technologies into the therapies and
vaccines that matter most. Whether you are in the discovery
sciences, ensuring drug safety and efficacy or supporting clinical
trials, you will apply cutting edge design and process development
capabilities to accelerate and bring the best in class medicines to
patients around the world.What You Will AchieveWe are looking for a
Senior Associate Scientist at the BS/MS level. You will be at the
center of our operations and you'll find that everything we do,
every day, is in line with an unwavering commitment to quality. You
will be responsible for supporting the preclinical evaluation and
early clinical development of candidate viral vaccines. You will
perform various assays to monitor the immune responses elicited by
vaccine candidates and maintaining cell lines, weekly processing of
red blood cells, and preparing samples for testing. You will also
assist with molecular and virology work to generate plasmid
constructs for RNA and reverse genetic virus stocks plus optimizing
RNA vaccines. Your skills and expertise will ensure that all work
is to be done in a compliant manner according to relevant Standard
Operating Procedure (SOP) guidelines and Good Lab Practices cGLP
and/or (Current) Good Manufacturing Practices (part of GxP) cGMP
guidelines.Your significant experience of applying knowledge of
principles, concepts, and practices of the discipline will make you
a critical member of the team. You are proactive in contributing to
all team discussions and creating an environment of
collaboration.It is your hard work and focus that will help in
making Pfizer ready to achieve new milestones and help patients
across the globe.How You Will Achieve It
- The candidate is expected to apply molecular biology and
biochemistry to advance our RNA-based vaccine platform, especially
the RNA vaccine design strategies optimization.
- Perform molecular techniques that include (but are not limited
to) recombinant DNA techniques, carry out gene synthesis, sequence
analysis, DNA/RNA isolation, RT-qPCR/ddPCR, RNA manipulation and
analysis.
- In collaboration with manager, interpret and summarize
experimental data. Present experimental results at group meetings
as needed.
- Generate and characterize reagents used to perform necessary
assays and support maintenance of laboratory supplies.
- Regular review of literature to maintain knowledge of
scientific trends and industry processes, advance molecular biology
and protein production methods.
- Maintain laboratory notebooks in compliance with the Pfizer
Laboratory Notebook Policy.
- Satisfactorily completes all cGMP/GLP and safety training in
conformance with departmental requirements Where applicable,
performs job responsibilities in compliance with cGMP/GLP and all
other regulatory agency requirements.
- Performs other duties as assigned.QualificationsMust-Have
- Degree in Molecular Biology, Biochemistry, Virology, or a
related scientific field.
- MS with 1-2 years of research experience, or BS with 4-6 years
of laboratory research experience, industry experience
preferred.
- Experience in biochemical assay development for manipulating
and analyzing RNA (e.g. IVT, RNA purification/quantification,
TapeStation, Bioanalyzer).
- Determine and analyze RNA structure and modification and
optimize RNA structure for functionality.
- Must be detail oriented; possess problem solving skills, and
the ability to handle multiple tasks.
- Strong written and oral communication skillsNice-to-Have
- Experience of ddPCR.
- Understanding of state-of-the-art gene synthesis.
- Understanding of mRNA UTR structure and function.
- Understanding of RNA modification and stabilization.
- Experience with cell culture and cell-based assays.Other Job
DetailsEligible for Relocation PackageEligible for Employee
Referral BonusPfizer requires all U.S. new hires to be fully
vaccinated for COVID-19 prior to the first date of employment. As
required by applicable law, Pfizer will consider requests for
Reasonable Accommodations.Sunshine ActPfizer reports payments and
other transfers of value to health care providers as required by
federal and state transparency laws and implementing regulations.
These laws and regulations require Pfizer to provide government
agencies with information such as a health care provider's name,
address and the type of payments or other value received, generally
for public disclosure. Subject to further legal review and
statutory or regulatory clarification, which Pfizer intends to
pursue, reimbursement of recruiting expenses for licensed
physicians may constitute a reportable transfer of value under the
federal transparency law commonly known as the Sunshine Act.
Therefore, if you are a licensed physician who incurs recruiting
expenses as a result of interviewing with Pfizer that we pay or
reimburse, your name, address and the amount of payments made
currently will be reported to the government. If you have questions
regarding this matter, please do not hesitate to contact your
Talent Acquisition representative.EEO & Employment
EligibilityPfizer is committed to equal opportunity in the terms
and conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify
employer.Research and Development
Keywords: Pfizer, New York , Senior Associate Scientist, RNA Biology - Viral Vaccine, Other , Pearl River, New York
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