Computational Biologist

Company: 3DC
Location: New York
Posted on: May 16, 2022

Job Description:

Deerfield Discovery and Development, LLC (3DC) engages in drug discovery research in collaboration with premier universities and biopharmaceutical companies across the United States. 3DC is the drug discovery arm of Deerfield Management Company, L.P. ("Deerfield"), an investment firm dedicated to advancing healthcare. The goal of 3DC is to enable portfolio companies of Deerfield's investment funds to create a pipeline of medically important and commercially viable projects at a scale sufficient to produce value for patients and investors. Project teams consist of scientists from a wide variety of disciplines (chemistry, biology, DMPK, toxicology, computational science, software and automation engineering), working together in a highly collaborative environment to advance these goals. Responsibilities

We are seeking a Computational Biologist to work with Matt Nelson, Vice President of Genetics and Genomics, to help develop novel insights into the role that genes play in disease and apply them to novel target discovery, target validation, portfolio prioritization, and to support private and public investment activities. This position is open to all levels of experience for candidates with a minimum of three years conducting bioinformatics research in the context of drug discovery and development.

• Take a leading role in the integration of insights from genetic and genomic data to support the identification of new drug targets, the review of proposed targets, the ongoing validation of existing targets, and identification of potential patient selection biomarkers
  • The ideal candidate will have recent experience supporting oncology drug discovery
  • Provide hands-on support to build out DF genetics and genomics databases
    • Develop analytics for common genetic and genomic data use cases and help integrate them into reusable applications
      • Provide genomic data analysis as needed to support DF discovery project review and progression, including consulting with academic labs to ensure sound methods and interpretation of data
      • Provide bioinformatics consulting for Deerfield portfolio companies that lack internal expertise
        • Provide training to Deerfield staff, portfolio companies, and collaborators in genomics applications
          • Participate in the development of the Deerfield drug discovery and development data strategy, including genetics, genomics, assays, chemistry, and clinical data
          • Contribute to private investment due diligence
          • Contribute to evaluation of clinical development programs Qualifications
            
            Minimum qualifications
            • PhD or equivalent training in computational biology, bioinformatics, biostatistics, genetics, or related area
            • Five years post-graduate research experience, including three years working in target discovery, target validation, and related applications to drug discovery, including work in oncology
            • Extensive experience conducting hands-on genomic data analysis with tools such as R, Python, and command-line tools
            • Broad knowledge of public and private genomic data sources and state-of-the-art analysis methods and tools Preferred qualifications
              • Experience working in or leading multidisciplinary teams
              • Publication record in peer reviewed journals
              • Strong understanding of genetic concepts and genome-wide approaches to genetic data analysis and interpretation 3DC provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, PM18#LI-DNI PI175003411

Keywords: 3DC, New York , Computational Biologist, Other , New York, New York